Seroatlas · Human Serome Atlas

FAM72C

Protein FAM72C

Also known as: FA72C_HUMAN, RP5-998N21.9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H0Y354
Gene
FAM72C
Ensembl
ENSG00000263513
Chromosome
1
Canonical length
149 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>H0Y354|FAM72C
     1  MSTNICSFKD RCVSILCCKF CKQVLSSRGM KAVLLADTEI DLFSTDIPPT NAVDFTGRCY
    61  FTKICKCKLK DIACLKCGNI VVYHVIVPCS SCLLSCNNRH FWMFHSQAVY DINRLDSTGV
   121  NVLLRGNLPE IEESTDEDVL NISAEECIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM72C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
4.9 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 4.9 nTPM
  • lymph node: 4 nTPM
  • tonsil: 3.9 nTPM
  • bone marrow: 2.7 nTPM
  • appendix: 1.5 nTPM
  • testis: 1.3 nTPM

Single-cell type

  • paneth cells: 7.7 nCPM
  • early primary spermatocytes: 6.8 nCPM
  • late primary spermatocytes: 6.8 nCPM
  • extravillous trophoblasts: 5.8 nCPM
  • differentiating spermatogonia: 4.6 nCPM
  • oocytes: 4.6 nCPM

Immune cell

  • T-reg: 0.4 nTPM
  • NK-cell: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • cerebellum: 0.5 nTPM
  • white matter: 0.4 nTPM
  • basal ganglia: 0.3 nTPM
  • cerebral cortex: 0.3 nTPM
  • hippocampal formation: 0.3 nTPM
  • pons: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0.36
gnomAD missense Z
0.49

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM72C as an antibody target. Whether an autoantibody or antibody against FAM72C could matter depends on whether native FAM72C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM72C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM72C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM72C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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