Seroatlas · Human Serome Atlas

FAM72B

Protein FAM72B

Also known as: FA72B_HUMAN, RP11-439A17.6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X60
Gene: FAM72B
Ensembl: ENSG00000188610
Chromosome: 1
Canonical length: 149 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q86X60|FAM72B
     1  MSTNICSFKD RCVSILCCKF CKQVLSSRGM KAVLLADTEI DLFSTDIPPT NAVDFTGRCY
    61  FTKICKCKLK DIACLKCGNI VGYHVIVPCS SCLPSCNNGH FWMFHSQAVY DINRLDSTGV
   121  NILLWGNLPE IEESTDEDVL NISAEECIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM72B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 9.6 nTPM

Expression across tissuesHPA

Tissue

thymus: 9.6 nTPM
lymph node: 7.6 nTPM
tonsil: 6.2 nTPM
bone marrow: 5.8 nTPM
appendix: 3.5 nTPM
cerebellum: 2.6 nTPM

Single-cell type

late primary spermatocytes: 32 nCPM
late spermatids: 31 nCPM
epicardial cells: 18 nCPM
kupffer cells: 13 nCPM
hofbauer cells: 12 nCPM
tuft cells: 12 nCPM

Immune cell

myeloid DC: 0.9 nTPM
classical monocyte: 0.6 nTPM
T-reg: 0.4 nTPM
non-classical monocyte: 0.3 nTPM
total PBMC: 0.3 nTPM
memory B-cell: 0.2 nTPM

Brain region

cerebellum: 3.3 nTPM
medulla oblongata: 2.5 nTPM
pons: 2.5 nTPM
white matter: 2.1 nTPM
choroid plexus: 2 nTPM
midbrain: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM72B as an antibody target. Whether an autoantibody or antibody against FAM72B could matter depends on whether native FAM72B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM72B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM72B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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