Seroatlas · Human Serome Atlas

FAM53A

Protein FAM53A

Also known as: DNTNP, FA53A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NSI3
Gene: FAM53A
Ensembl: ENSG00000174137
Chromosome: 4
Canonical length: 398 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in protein import into nucleus. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>Q6NSI3|FAM53A
     1  MVTLITEKLQ SQSLDDLTCK AEAGPLQYSA ETLNKSGRLF PLELNDQSPW KVFSGGPPVR
    61  SQAATGPDFS FLPGLSAAAH TMGLQWQPQS PRPGAGLGAA STVDPSESTG SSTAPPTKRH
   121  CRSLSEPEEL VRCRSPWRPG SSKVWTPVSK RRCDSGGSAT RQGSPGAVLP RSAVWSTGPT
   181  SPATPRPSSA SGGFVDSSEG SAGSGPLWCS AESCLPSTRR RPSLSQERLA GAGTPLPWAS
   241  SSPTSTPALG GRRGLLRCRS QPCVLSGKRS RRKRRREEDA RWTRPSLDFL KMTQTLKNSK
   301  SLCSLNYEDD DEDDTPVKTV LSSPCDSRGL PGITMPGCSQ RGLRTSPVHP NLWASRESVT
   361  SDGSRRSSGD PRDGDSVGEE GVFPRARWEL DLEQIENN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM53A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
pituitary gland: 5.7 nTPM
thyroid gland: 3.8 nTPM
spinal cord: 2.5 nTPM
liver: 1.8 nTPM
midbrain: 1.7 nTPM

Single-cell type

lactotrophs: 35 nCPM
early primary spermatocytes: 31 nCPM
somatotrophs: 27 nCPM
thyrotrophs: 19 nCPM
differentiating spermatogonia: 15 nCPM
oligodendrocytes: 13 nCPM

Immune cell

plasmacytoid DC: 1.7 nTPM
naive CD4 T-cell: 1.1 nTPM
intermediate monocyte: 1 nTPM
myeloid DC: 0.7 nTPM
memory B-cell: 0.5 nTPM
naive B-cell: 0.5 nTPM

Brain region

white matter: 8.8 nTPM
medulla oblongata: 7.2 nTPM
pons: 6.4 nTPM
midbrain: 6.1 nTPM
basal ganglia: 6 nTPM
thalamus: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.44
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein import into nucleus

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM53A as an antibody target. Whether an autoantibody or antibody against FAM53A could matter depends on whether native FAM53A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM53A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM53A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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