Seroatlas · Human Serome Atlas

FAM47C

Putative protein FAM47C

Also known as: FA47C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5HY64
Gene
FAM47C
Ensembl
ENSG00000198173
Chromosome
X
Canonical length
1035 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a product belonging to a family of proteins with unknown function. The coding sequence of this family member includes several tandemly repeated regions. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

1035 residues, UniProt reviewed canonical sequence.

>Q5HY64|FAM47C
     1  MGDQRPQDRP SSPGMDSTPW YCDKPPSKYF AKRKHRRLRF PPVDTQNWVF VTEGMDDFRY
    61  GCQSPEDTLV CRRDEFLLPK ISLRGPQADP KSRKKKLLKK AALFSKLSPA QPARKAFVEE
   121  VEAQLMTKHP LAMYPNLGED MPPDLLLQVL KPLDPERKLE DAGSCEGQEK TTDEPTEPGK
   181  YPCGEFSPRP PETRVSCLPP EPPKTPVSSL RPEPPETGVS HLRPQPPKTQ VSSLHLEPPE
   241  TGVSHLRPEP PKTQVSSLHL EPPETGVSHL YLEPPGTGVS HLCPEPPKTR VSHLHREPPE
   301  TGVPDLCLEP PKSRVSHLRP EPSETGVSHL HPEPPKTLVS SLHPEPPETG VSHLCPEPPE
   361  TRVSPLRQLP PEAGVSHLCP EPPKTRVPPL RPETPKNGVS PLFPEPPKTR ISNLRSEPPK
   421  IGVSHLCLEP PKTRGSHLRP EPPETGVSHL RPEPPKTRVS SLHLEPPETG VSHLCPEPPE
   481  KDVSHLRPEP PDTGVSHLCP EPPKTRVSHL RPEPSETGVS HLRPEPPKIL VSSLHQAPPE
   541  SSVSHLRPEP PETGVSHLRP EPPKTRMYSL RPEPPDTGVS HLCPEPPKTR VSSLPPEPPE
   601  TGVSHLCPEP PETRVSHLRP EPPETGVSHL RPEPPKTRMY SLRPEPPNTG VSHLCPEPPK
   661  TRVSSLPPEP PETGVSHLCP EPPETRVSHL RPEPPETGVS RLHPEPPKTR VSSLHAEPPE
   721  SRVSHLCPEP PETGVSHLRP EPPKPRVSSL RPEPLETRVS HLRPEPPETG VSHLHPELPK
   781  PRVSSLHLEP PKTRRVSSLR LEPPKTGRVS SLCPEPTKTG ASHLKELFQE GTSSTMECVS
   841  DSLQRRHTSR KLRDFKWAGD LGVNEESISS LFDFTPECRA TYQDQKNKKA NECSSGLKYS
   901  MELDEMDEVK FFSQEKDLDG KIQNAPNSHS AQHVKMGYGA WYLKPKLGKK LRSDEPLIDP
   961  KLVLEKPDEP DILDGLYGPI AFKDFILSKG YEMPGIIQRL FARRGWTYDS VKTPIQRAMQ
  1021  VYKYKEDVTD ASEED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM47C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
2.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2.7 nTPM
  • pituitary gland: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late primary spermatocytes: 8.8 nCPM
  • early spermatids: 7.8 nCPM
  • late spermatids: 3.4 nCPM
  • breast myoepithelial cells: 0.9 nCPM
  • sertoli cells: 0.3 nCPM
  • early primary spermatocytes: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.53
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM47C as an antibody target. Whether an autoantibody or antibody against FAM47C could matter depends on whether native FAM47C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM47C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM47C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM47C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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