Seroatlas · Human Serome Atlas

FAM47B

Protein FAM47B

Also known as: FA47B_HUMAN, FLJ35782

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA70
Gene: FAM47B
Ensembl: ENSG00000189132
Chromosome: X
Canonical length: 645 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM47B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

645 residues, UniProt reviewed canonical sequence.

>Q8NA70|FAM47B
     1  MGDRRPQDRP RSQGMDSKPW YCDKPPSKYF AKRKHRRLRF PPVDTQNWVF VTEGMDDFRY
    61  ACQSPEDTLV CRRDEFLLPK ISLRGPQADR KSRKKKLLKK AALFSELSPV QPARKAFVEE
   121  VEAQLMTKHP LAMYPNLGKD MPPDLLLQVL KQLDPERKLE DAWARCEARE KTTEVPTESG
   181  KYPCGESCPR PPETPVSRLR PQLPKTPVSS RRPEPPKTRV SSLRPEPPKT RVSSLHPEPP
   241  ETRASHLRVD PPETGVSHLC PEPPKTLVSS VHPEPPDTGA SHLCPEPPET RVSHLHPEPP
   301  ETGVSHLRPE PSKTQVSSLC PEPPEAGVSH LCLEPPNTHR VSSFLLQVLK LDSEKKLEDA
   361  RARCEGQEMT TEELTKPGKY HFWESCPRPF ESRMPHLRLV LPITRRMASL CLKPPKTRRV
   421  SSLCPEPTKT GASHLKELFQ EDTPSTMECV SDSLQRRHTS RKLRDFKWAG DLGVNEESIS
   481  SLFDFTPECR TTDQDQKIKK ANECASRLMY GMELDDMDEV EFLRIKYWDR RRRAAPHSYS
   541  AQRGRIRYGP WYFEPKLGKK LRSDEPLIDP KPVLEKPDEP DILDGLYGPI AFKDFILSKG
   601  YRMPGVIEKL FAKKGWTYDS VKTPIQRAVQ VYKYKEDVTD ASKED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM47B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 8.8 nTPM

Expression across tissuesHPA

Tissue

testis: 8.8 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 49 nCPM
late spermatids: 40 nCPM
late primary spermatocytes: 39 nCPM
early primary spermatocytes: 0.3 nCPM
leydig cells: 0.1 nCPM
pericytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.71
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM47B as an antibody target. Whether an autoantibody or antibody against FAM47B could matter depends on whether native FAM47B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM47B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM47B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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