Seroatlas · Human Serome Atlas

FAM47A

Protein FAM47A

Also known as: FA47A_HUMAN, MGC27003

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JRC9
Gene: FAM47A
Ensembl: ENSG00000185448
Chromosome: X
Canonical length: 791 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM47A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

791 residues, UniProt reviewed canonical sequence.

>Q5JRC9|FAM47A
     1  MGDQRLQDWL RSPGMDSKPW YCNKRPSKCF AKCKHRRLRF PPMDTQNWVF VKEGMDDFRY
    61  GCPSPEDTLV CRRDEFLLPK ISLRGPQADP KSGQKKLLKK AALFSKLSPA QLARKAFVEQ
   121  VEAQLMAKHP LAMYPNLGED MPPDLLLQVL KHLDPERELE DAWACCETQE KTTEVPTEPG
   181  KHPCGEFCLK PPETPVSHLL PEPPETGVSH LSPEPPKTPV SSLRPEPPET GVSHLRPEPP
   241  ETGVSHIRPG PPITRRRSSL LRQLLKLDSE RKLEDARAPC EGREKTTDEP TEPGKYPCGK
   301  FCPRPFETPL SHLRQEPPKT PVSSLRPEPP ETGESHLRLE HSKTRRGSSL RSEPSETGVS
   361  RLRLAPPKTR RGSSLHAEPS KTGVSHLSPE PPKTEVSHLH PVPPKTGVCH LRLEPPDTSQ
   421  VSNLLLYILK VLDSGRTLKD VWDRCEARVK KTKEPTEPHK SPCGEPCLQP PETQVSHPHP
   481  EHPKTRRRSS LHSQPPKTRR TSSLRSEPPK TRRTSSLRSE PPKTRRTSSL GPEPPKTRRV
   541  SSLRPELPKS RRVSSLHPEP PKAPESHQFS EPPKIRASYI KELLQEDTPS TKECVSDSLQ
   601  YRYTSEKLRE FFKWAGDLGA DEESIRNLFD FTPKYRATHE DQKFKKVKEC SSELKYSMEL
   661  DEKDEDKFFS QEKYWGRKFH TPSNSYTAQR VKMKYGAWYL KPKLWKKLRS DEPLIDPKLL
   721  LKKPDEPDVL DDLYGPIAFK DFILSKGYEM PGIIQRLFAR RGWTYDSVKT PIQRAMIFYK
   781  YKEIVEASEE D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM47A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

testis: 2.7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 9.8 nCPM
late primary spermatocytes: 8.5 nCPM
late spermatids: 3.5 nCPM
cardiomyocytes: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM
vascular endothelial cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.6 nTPM
hippocampal formation: 1.1 nTPM
white matter: 1.1 nTPM
amygdala: 1 nTPM
basal ganglia: 1 nTPM
medulla oblongata: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.08
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM47A as an antibody target. Whether an autoantibody or antibody against FAM47A could matter depends on whether native FAM47A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM47A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM47A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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