Seroatlas · Human Serome Atlas

FAM27E3

Protein FAM27E3

Also known as: F27E3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08E93
Gene: FAM27E3
Canonical length: 113 aa

OverviewNCBI Gene

No narrative summary is available for FAM27E3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q08E93|FAM27E3
     1  MGIFQLLRDR RISSRGPGLH TPKAEPRRRK GLTTGLMTQA ERQKQAHQRQ AAMRETALWC
    61  TGHIRPRTHT HTGTHTQTDR ERERNTQRLR DRERRENGRH THTYTHRHTH RVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM27E3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM27E3 as an antibody target. Whether an autoantibody or antibody against FAM27E3 could matter depends on whether native FAM27E3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM27E3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM27E3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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