Seroatlas · Human Serome Atlas

FAM27D1

Protein FAM27D1

Also known as: F27D1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T7N8
Gene: FAM27D1
Canonical length: 215 aa

OverviewNCBI Gene

No narrative summary is available for FAM27D1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q5T7N8|FAM27D1
     1  MLEKRLLRMG MRLQLLRDRR ISSRGPGLHR AKADPQQQKR LTTGLMTQAE TQKEAQQRQA
    61  AMRKTALWHT GHLQPKTHTH TGMHTQTHRE RERNTQRLRD RERRENGRHT HRHTHTLTHT
   121  HTHRDTHTAS YRRGIETHTT RQPLRLRGSA HDENDPRVRE QPRGTQADLS SRSRMAARLL
   181  GRLTPTNTVR AGLRLGSRAA SPDPAWGFLI VVGPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM27D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM27D1 as an antibody target. Whether an autoantibody or antibody against FAM27D1 could matter depends on whether native FAM27D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM27D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM27D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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