FAM27B
Protein FAM27A/B/C
Also known as: FAM27_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for FAM27B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
67 residues, UniProt reviewed canonical sequence.
>Q5VT28|FAM27B
1 MRKPQAGTGE AARDPSLRPA RTVLVGDQDE YTAAENKSPR GTLCPTGEQR IHAREDACIF
61 SRLFSEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM27B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0.06
- gnomAD missense Z
- -0.31
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM27B as an antibody target. Whether an autoantibody or antibody against FAM27B could matter depends on whether native FAM27B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM27B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM27B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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