Seroatlas · Human Serome Atlas

FAM25A

Protein FAM25A

Also known as: bA96C23.5, FM25A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
B3EWG3
Gene
FAM25A
Ensembl
ENSG00000188100
Chromosome
10
Canonical length
89 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM25A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>B3EWG3|FAM25A
     1  MLGGLGKLAA EGLAHRTEKA TEGAIHAVEE VVKEVVGHAK ETGEKAIAEA IKKAQESGDK
    61  KMKEITETVT NTVTNAITHA AESLDKLGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM25A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
510 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 510 nTPM
  • cervix: 200 nTPM
  • vagina: 179 nTPM
  • skin: 173 nTPM
  • salivary gland: 123 nTPM
  • tonsil: 62 nTPM

Single-cell type

  • esophageal apical cells: 1,431 nCPM
  • suprabasal keratinocytes: 36 nCPM
  • esophageal suprabasal cells: 10 nCPM
  • syncytiotrophoblasts: 5.4 nCPM
  • esophageal basal cells: 1.8 nCPM
  • gastric progenitor cells: 1.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.6 nTPM
  • white matter: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • thalamus: 0.4 nTPM
  • hypothalamus: 0.3 nTPM
  • amygdala: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0.2
gnomAD missense Z
0.7
DepMap mean gene effect
-0.33
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM25A as an antibody target. Whether an autoantibody or antibody against FAM25A could matter depends on whether native FAM25A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM25A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM25A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM25A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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