Seroatlas · Human Serome Atlas

FAM24B

Protein FAM24B

Also known as: AC073585.2, FA24B_HUMAN, MGC45962

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N5W8
Gene
FAM24B
Ensembl
ENSG00000213185
Chromosome
10
Canonical length
94 aa
Protein class
Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

94 residues, UniProt reviewed canonical sequence.

>Q8N5W8|FAM24B
     1  MPVIAGGILA ALLLLIVVVL CLYFKIHNAL KAAKEPEAVA VKNHNPDKVW WAKNSQAKTI
    61  ATESCPALQC CEGYRMCASF DSLPPCCCDI NEGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM24B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 15 nTPM
  • pituitary gland: 11 nTPM
  • pancreas: 11 nTPM
  • testis: 9.4 nTPM
  • spinal cord: 6.7 nTPM
  • hippocampal formation: 5.5 nTPM

Single-cell type

  • respiratory ionocytes: 46 nCPM
  • late primary spermatocytes: 27 nCPM
  • renal collecting duct intercalated cells: 27 nCPM
  • epididymal clear cells: 12 nCPM
  • oligodendrocytes: 10 nCPM
  • brain inhibitory neurons: 10 nCPM

Immune cell

  • plasmacytoid DC: 8.1 nTPM
  • memory B-cell: 4.2 nTPM
  • T-reg: 3.6 nTPM
  • naive CD4 T-cell: 3.5 nTPM
  • memory CD4 T-cell: 3.4 nTPM
  • memory CD8 T-cell: 2.4 nTPM

Brain region

  • hypothalamus: 6.6 nTPM
  • white matter: 5.3 nTPM
  • medulla oblongata: 4.3 nTPM
  • hippocampal formation: 4.2 nTPM
  • pons: 4.2 nTPM
  • thalamus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.9
gnomAD pLI
0.09
gnomAD missense Z
0.49
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM24B as an antibody target. Whether an autoantibody or antibody against FAM24B could matter depends on whether native FAM24B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM24B is annotated as secreted, so native FAM24B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM24B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM24B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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