Seroatlas · Human Serome Atlas

FAM24A

Protein FAM24A

Also known as: AC073585.4, FA24A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NFZ4
Gene
FAM24A
Ensembl
ENSG00000203795
Chromosome
10
Canonical length
105 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>A6NFZ4|FAM24A
     1  MAKMFDLRTK IMIGIGSSLL VAAMVLLSVV FCLYFKVAKA LKAAKDPDAV AVKNHNPDKV
    61  CWATNSQAKA TTMESCPSLQ CCEGCRMHAS SDSLPPCCCD INEGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM24A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late primary spermatocytes: 383 nCPM
  • early spermatids: 157 nCPM
  • late spermatids: 13 nCPM
  • sertoli cells: 1.4 nCPM
  • leydig cells: 1.1 nCPM
  • peritubular myoid cells: 0.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • pons: 0.4 nTPM
  • thalamus: 0.4 nTPM
  • white matter: 0.4 nTPM
  • cerebellum: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0.02
gnomAD missense Z
0.24
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM24A as an antibody target. Whether an autoantibody or antibody against FAM24A could matter depends on whether native FAM24A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM24A is annotated as secreted, so native FAM24A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM24A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM24A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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