Seroatlas · Human Serome Atlas

FAM246C

Protein FAM246C

Also known as: F246C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DSO1
Gene
FAM246C
Canonical length
240 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM246C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>P0DSO1|FAM246C
     1  MAEPGRPWAQ ARSAYRASEV LRRGTGRRRD PGPQSNGPGQ EDARAPGRMA RLRGQLRAEA
    61  ASRSEVPRLL KLVERAGAGA AGRGREDRRA QPRAPCARYA GSPAAGPPTR RGSWRSASGG
   121  CRRAWRQCAR SWAPGLRRCA RSFERSWMPC ARCCRRRRPR LPAASPAPSP APRPAARPCR
   181  GRSAPLAPWS PPPGPQTTPR TAQQNAERTE PRPGRTTRRC QCRLGPRKVA GTEGGRTRAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM246C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
1.6 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 1.6 nTPM
  • retina: 1.1 nTPM
  • liver: 1 nTPM
  • testis: 1 nTPM
  • kidney: 0.7 nTPM
  • pancreas: 0.5 nTPM

Single-cell type

  • late spermatids: 0.3 nCPM
  • pancreatic islet cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 14 nTPM
  • cerebral cortex: 10 nTPM
  • pons: 8.7 nTPM
  • amygdala: 8.6 nTPM
  • medulla oblongata: 8.1 nTPM
  • hippocampal formation: 8 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM246C as an antibody target. Whether an autoantibody or antibody against FAM246C could matter depends on whether native FAM246C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM246C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM246C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM246C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...