Seroatlas · Human Serome Atlas

FAM246A

Protein FAM246A

Also known as: F246A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A494C0Y3
Gene
FAM246A
Ensembl
ENSG00000286102
Chromosome
22
Canonical length
232 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM246A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

232 residues, UniProt reviewed canonical sequence.

>A0A494C0Y3|FAM246A
     1  MATPGRPWAQ ARSAYRASEV LRRVTGRRRD PGPQSNGPGQ EDARAPGRLA RLLGQLRAEA
    61  ASRSEVPRLL KLVERAGAGA AGAGERTGAH SRGSVCSVCG EPRGRATYPA GVLEVSERRL
   121  QEGLAAVREE LGAEIEALRA ELRAELDALR ALLPPPPPSP PARREPRAVP RATPRGPTLL
   181  RTLGTVSALV AASRPADDAP DGPAECGAHR APVRKNHKKM PVPPGAPQGG GD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM246A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.2 nTPM
  • cerebellum: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • epididymal efferent duct ciliated cells: 0.4 nCPM
  • early spermatids: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 2.6 nTPM
  • medulla oblongata: 1.9 nTPM
  • cerebral cortex: 1.8 nTPM
  • spinal cord: 0.9 nTPM
  • basal ganglia: 0.7 nTPM
  • midbrain: 0.7 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM246A as an antibody target. Whether an autoantibody or antibody against FAM246A could matter depends on whether native FAM246A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM246A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM246A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM246A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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