Seroatlas · Human Serome Atlas

FAM241B

Protein FAM241B

Also known as: C10orf35, F241B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96D05
Gene
FAM241B
Ensembl
ENSG00000171224
Chromosome
10
Canonical length
121 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>Q96D05|FAM241B
     1  MVRILANGEI VQDDDPRVRT TTQPPRGSIP RQSFFNRGHG APPGGPGPRQ QQAGARLGAA
    61  QSPFNDLNRQ LVNMGFPQWH LGNHAVEPVT SILLLFLLMM LGVRGLLLVG LVYLVSHLSQ
   121  R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM241B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 73 nTPM
  • cerebral cortex: 42 nTPM
  • hypothalamus: 37 nTPM
  • hippocampal formation: 31 nTPM
  • amygdala: 28 nTPM
  • basal ganglia: 28 nTPM

Single-cell type

  • early spermatids: 118 nCPM
  • oocytes: 46 nCPM
  • early primary spermatocytes: 31 nCPM
  • breast myoepithelial cells: 31 nCPM
  • retinal pigment epithelial cells: 30 nCPM
  • other brain neurons: 29 nCPM

Immune cell

  • naive CD4 T-cell: 17 nTPM
  • MAIT T-cell: 11 nTPM
  • memory CD4 T-cell: 11 nTPM
  • T-reg: 7.8 nTPM
  • memory CD8 T-cell: 7 nTPM
  • naive CD8 T-cell: 5.8 nTPM

Brain region

  • cerebral cortex: 58 nTPM
  • hippocampal formation: 47 nTPM
  • hypothalamus: 40 nTPM
  • cerebellum: 37 nTPM
  • pons: 33 nTPM
  • basal ganglia: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0.02
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM241B as an antibody target. Whether an autoantibody or antibody against FAM241B could matter depends on whether native FAM241B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM241B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM241B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM241B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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