Seroatlas · Human Serome Atlas

FAM240C

Protein FAM240C

Also known as: F240C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVR7
Gene
FAM240C
Ensembl
ENSG00000216921
Chromosome
2
Canonical length
95 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for FAM240C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>A0A1B0GVR7|FAM240C
     1  MVGKNMSKSL TLKNPGRVAY DSGGIKMFWE KKIEHHARHL QNEDIRVRRS ALNKLRVGWA
    61  EQLEGRNKML QGPGRCPDRV PEATESLHTK DKKAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM240C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
210 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 210 nTPM
  • pancreas: 35 nTPM
  • skeletal muscle: 11 nTPM
  • amygdala: 10 nTPM
  • basal ganglia: 9.5 nTPM
  • midbrain: 8 nTPM

Single-cell type

  • myosatellite cells: 9.5 nCPM
  • late spermatids: 8.4 nCPM
  • thymic myoid cells: 6.8 nCPM
  • astrocytes: 2.2 nCPM
  • pancreatic acinar cells: 1.9 nCPM
  • parietal cells: 1.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 7 nTPM
  • cerebellum: 6 nTPM
  • midbrain: 6 nTPM
  • pons: 6 nTPM
  • medulla oblongata: 5.6 nTPM
  • thalamus: 5.6 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM240C as an antibody target. Whether an autoantibody or antibody against FAM240C could matter depends on whether native FAM240C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM240C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM240C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM240C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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