Seroatlas · Human Serome Atlas

FAM240B

Protein FAM240B

Also known as: F240B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVZ2
Gene
FAM240B
Ensembl
ENSG00000283329
Chromosome
9
Canonical length
78 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM240B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

78 residues, UniProt reviewed canonical sequence.

>A0A1B0GVZ2|FAM240B
     1  MNNQYIRREV FCCGTCHELK SFWEKEISKQ TFYRELEEDR QERSALKKLR EEWRQRLERR
    61  LRMLDNPVEK EKPAHTAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM240B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 0.6 nTPM
  • bone marrow: 0.5 nTPM
  • skin: 0.4 nTPM
  • testis: 0.4 nTPM
  • skeletal muscle: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM

Single-cell type

  • thymic myoid cells: 6.8 nCPM
  • undifferentiated spermatogonia: 3.2 nCPM
  • epicardial cells: 2.3 nCPM
  • late primary spermatocytes: 1 nCPM
  • cardiomyocytes: 0.9 nCPM
  • late spermatids: 0.9 nCPM

Immune cell

  • basophil: 4.2 nTPM
  • neutrophil: 1.6 nTPM
  • eosinophil: 0.7 nTPM
  • plasmacytoid DC: 0.7 nTPM
  • naive B-cell: 0.6 nTPM
  • memory B-cell: 0.5 nTPM

Brain region

  • cerebellum: 3.7 nTPM
  • white matter: 3.1 nTPM
  • cerebral cortex: 2.9 nTPM
  • basal ganglia: 2.4 nTPM
  • hippocampal formation: 2.4 nTPM
  • midbrain: 2.4 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM240B as an antibody target. Whether an autoantibody or antibody against FAM240B could matter depends on whether native FAM240B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM240B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM240B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM240B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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