Seroatlas · Human Serome Atlas

FAM240A

Protein FAM240A

Also known as: F240A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVK7
Gene
FAM240A
Ensembl
ENSG00000283473
Chromosome
3
Canonical length
83 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM240A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

83 residues, UniProt reviewed canonical sequence.

>A0A1B0GVK7|FAM240A
     1  MRLFSGMNNQ YTRREVFCRN TCHDLKHFWE REIGKQTYYR ESEERRLGRS ALRKLREEWK
    61  QRLETKLRLR NNPEDTEKRT NVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM240A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
0.7 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 0.7 nTPM
  • breast: 0.4 nTPM
  • adipose tissue: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • kidney: 0.1 nTPM
  • pituitary gland: 0.1 nTPM

Single-cell type

  • breast lactating cells: 25 nCPM
  • myosatellite cells: 4.6 nCPM
  • medullary thymic epithelial cells: 2.4 nCPM
  • gastric chief cells: 1.1 nCPM
  • salivary ionocytes: 0.7 nCPM
  • breast secretory cells: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 9.9 nTPM
  • cerebellum: 6.6 nTPM
  • hippocampal formation: 6.4 nTPM
  • white matter: 6 nTPM
  • basal ganglia: 5.8 nTPM
  • amygdala: 5.4 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM240A as an antibody target. Whether an autoantibody or antibody against FAM240A could matter depends on whether native FAM240A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM240A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM240A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM240A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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