Seroatlas · Human Serome Atlas

FAM237B

Protein FAM237B

Also known as: F237B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVD1
Gene
FAM237B
Ensembl
ENSG00000283267
Chromosome
7
Canonical length
139 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>A0A1B0GVD1|FAM237B
     1  MCFATRRWFY LHLGCMMLIN LVNADFEFQK GVLASISPGI TKDIDLQCWK ACSLTLIDLK
    61  ELKIEHNVDA FWNFMLFLQK SQRPGHYNVF LNIAQDFWDM YVDCLLSRSH GMGRRQVMPP
   121  KYNFPQKITG GNLNVYLRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM237B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • retina: 0.5 nTPM
  • prostate: 0.4 nTPM
  • fallopian tube: 0.2 nTPM
  • pituitary gland: 0.2 nTPM
  • testis: 0.2 nTPM
  • adipose tissue: 0.1 nTPM

Single-cell type

  • epicardial cells: 34 nCPM
  • müller glia: 14 nCPM
  • early spermatids: 3.2 nCPM
  • late primary spermatocytes: 2.8 nCPM
  • endometrial ciliated cells: 1.9 nCPM
  • cardiomyocytes: 1.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 1.1 nTPM
  • cerebral cortex: 0.9 nTPM
  • midbrain: 0.6 nTPM
  • white matter: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • choroid plexus: 0.5 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM237B as an antibody target. Whether an autoantibody or antibody against FAM237B could matter depends on whether native FAM237B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM237B is annotated as secreted, so native FAM237B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM237B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM237B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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