Seroatlas · Human Serome Atlas

FAM237A

Protein FAM237A

Also known as: F237A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTK4
Gene
FAM237A
Ensembl
ENSG00000235118
Chromosome
2
Canonical length
181 aa
Protein class
Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>A0A1B0GTK4|FAM237A
     1  MADPGNRGGI HRPLSFTCSL LIVGMCCVSP FFCHSQTDLL ALSQADPQCW ESSSVLLLEM
    61  WKPRVSNTVS GFWDFMIYLK SSENLKHGAL FWDLAQLFWD IYVDCVLSRN HGLGRRQLVG
   121  EEEKISAAQP QHTRSKQGTY SQLLRTSFLK KKELIEDLIS MHVRRSGSSV IGKVNLEIKR
   181  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM237A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
1.8 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 1.8 nTPM
  • cerebral cortex: 0.6 nTPM
  • hippocampal formation: 0.5 nTPM
  • hypothalamus: 0.5 nTPM
  • amygdala: 0.4 nTPM
  • heart muscle: 0.4 nTPM

Single-cell type

  • late primary spermatocytes: 8.3 nCPM
  • early spermatids: 5.2 nCPM
  • late spermatids: 3.8 nCPM
  • other brain neurons: 2.4 nCPM
  • sertoli cells: 1.1 nCPM
  • brain inhibitory neurons: 1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.4 nTPM
  • basal ganglia: 1.1 nTPM
  • hypothalamus: 0.9 nTPM
  • hippocampal formation: 0.5 nTPM
  • white matter: 0.4 nTPM
  • amygdala: 0.3 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM237A as an antibody target. Whether an autoantibody or antibody against FAM237A could matter depends on whether native FAM237A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM237A is annotated as secreted, so native FAM237A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM237A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM237A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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