Seroatlas · Human Serome Atlas

FAM236D

Protein FAM236D

Also known as: F236D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTK5
Gene
FAM236D
Ensembl
ENSG00000225396
Chromosome
X
Canonical length
79 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM236D in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>A0A1B0GTK5|FAM236D
     1  MIFTPFLPPA DLSVFQNVKG PQKDPEELVA VSDTAEDPSS GTGLPREPAL LRGSWRSRFQ
    61  RALACFIKCF RGGYRALGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM236D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
2.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2.3 nTPM
  • cerebellum: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • sertoli cells: 6.5 nCPM
  • early spermatids: 0.7 nCPM
  • late spermatids: 0.5 nCPM
  • late primary spermatocytes: 0.4 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • eosinophil: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 4.3 nTPM
  • cerebellum: 3.3 nTPM
  • cerebral cortex: 3.3 nTPM
  • basal ganglia: 3.2 nTPM
  • amygdala: 2.8 nTPM
  • hippocampal formation: 2.8 nTPM

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM236D as an antibody target. Whether an autoantibody or antibody against FAM236D could matter depends on whether native FAM236D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM236D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM236D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM236D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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