FAM236A
Protein FAM236A
Also known as: DMRTC1-AS1, F236A_HUMAN, LINC00684
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1B0GUQ0
- Gene
- FAM236A
- Ensembl
- ENSG00000275520
- Chromosome
- X
- Canonical length
- 79 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for FAM236A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
79 residues, UniProt reviewed canonical sequence.
>A0A1B0GUQ0|FAM236A
1 MIFTPFLPPA DLSVFQNVKG LQNDPEEWVA VSDATEDPSG GTGLPREPAL LRGSWRSRFQ
61 RALACFTKCF RGGYRALGILocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM236A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 145 nTPM
Expression across tissuesHPA
Tissue
- testis: 145 nTPM
- lymph node: 1.8 nTPM
- retina: 1.4 nTPM
- pancreas: 1.1 nTPM
- thyroid gland: 0.8 nTPM
- endometrium: 0.6 nTPM
Single-cell type
- sertoli cells: 25 nCPM
- late spermatids: 15 nCPM
- late primary spermatocytes: 5.2 nCPM
- early spermatids: 4.4 nCPM
- leydig cells: 0.7 nCPM
- peritubular myoid cells: 0.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 2.3 nTPM
- choroid plexus: 1.5 nTPM
- hippocampal formation: 0.9 nTPM
- pons: 0.9 nTPM
- thalamus: 0.8 nTPM
- basal ganglia: 0.6 nTPM
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM236A as an antibody target. Whether an autoantibody or antibody against FAM236A could matter depends on whether native FAM236A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM236A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM236A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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