Seroatlas · Human Serome Atlas

FAM234B

Protein FAM234B

Also known as: F234B_HUMAN, KIAA1467

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A2RU67
Gene
FAM234B
Ensembl
ENSG00000084444
Chromosome
12
Canonical length
622 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be located in Golgi apparatus; membrane; and microtubule organizing center. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

622 residues, UniProt reviewed canonical sequence.

>A2RU67|FAM234B
     1  MATVLSRALK LPGKKSPDLG EYDPLTQADS DESEDDLVLN LQKNGGVKNG KSPLGEAPEP
    61  DSDAEVAEAA KPHLSEVTTE GYPSEPLGGL EQKAASSLVS YVRTSVFLLT LGISMILVLL
   121  CAFLIPCPPR DLHSTWSRHL GSQGGGDLSP LELADVNGDG LRDVLLSFVM SRNGSAVGVS
   181  RPAANLVCLS GMNGSTLWSS LLPEEARDIT CLELMPGSLA ETICLVTGTH KMLSAFNATS
   241  GKAIWTLNPN YLSNGTLAAP VVVLPDLDED GVRDLVVLAI GELQPDLCFL LVSGRTGNPV
   301  GRPVKYNIVG VGNLIGPQVY ITTNGAVYIL FGFGNIQAVA LRDIFVQAQN RDSSPPSLQI
   361  EEPEWEKRRS INLSELIDVY SDGVELLQMV KAPDSNCSNL LITTRQSLVL LRGQNLTPYW
   421  ALRLQGLRSQ PTPGYFTDDQ TLDFLLQIQD GVGMKKMMVV DGDSGSIVWS YRAPCHMKET
   481  PATSAVTSDQ KSVFLFWAEG LSAASPNSDI ILGTEPPSLH HLYLLHPAFP SILLDLANTT
   541  GTVTASEVGI NDLWKDAFYV TRTTGPSSEG HPAALVVSKL SLRWALMEGQ MAQLQESTPK
   601  IGRGELRRFL SRIKFVEAPY EI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM234B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 22 nTPM
  • cerebellum: 21 nTPM
  • retina: 16 nTPM
  • breast: 15 nTPM
  • basal ganglia: 15 nTPM
  • skin: 12 nTPM

Single-cell type

  • early spermatids: 103 nCPM
  • breast lactating cells: 53 nCPM
  • retinal bipolar cells: 45 nCPM
  • late spermatids: 41 nCPM
  • epicardial cells: 32 nCPM
  • brain excitatory neurons: 32 nCPM

Immune cell

  • non-classical monocyte: 4.2 nTPM
  • naive B-cell: 3.4 nTPM
  • intermediate monocyte: 2.5 nTPM
  • memory B-cell: 2.4 nTPM
  • naive CD8 T-cell: 2.3 nTPM
  • plasmacytoid DC: 2.3 nTPM

Brain region

  • cerebral cortex: 62 nTPM
  • hypothalamus: 49 nTPM
  • hippocampal formation: 47 nTPM
  • basal ganglia: 45 nTPM
  • white matter: 41 nTPM
  • thalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.03
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM234B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM234B as an antibody target. Whether an autoantibody or antibody against FAM234B could matter depends on whether native FAM234B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM234B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM234B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM234B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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