Seroatlas · Human Serome Atlas

FAM234A

Protein FAM234A

Also known as: C16orf9, DKFZP761D0211, F234A_HUMAN, FLJ32603, ITFG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0X4
Gene: FAM234A
Ensembl: ENSG00000167930
Chromosome: 16
Canonical length: 552 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>Q9H0X4|FAM234A
     1  MLDHKDLEAE IHPLKNEERK SQENLGNPSK NEDNVKSAPP QSRLSRCRAA AFFLSLFLCL
    61  FVVFVVSFVI PCPDRPASQR MWRIDYSAAV IYDFLAVDDI NGDRIQDVLF LYKNTNSSNN
   121  FSRSCVDEGF SSPCTFAAAV SGANGSTLWE RPVAQDVALV ECAVPQPRGS EAPSACILVG
   181  RPSSFIAVNL FTGETLWNHS SSFSGNASIL SPLLQVPDVD GDGAPDLLVL TQEREEVSGH
   241  LYSGSTGHQI GLRGSLGVDG ESGFLLHVTR TGAHYILFPC ASSLCGCSVK GLYEKVTGSG
   301  GPFKSDPHWE SMLNATTRRM LSHSSGAVRY LMHVPGNAGA DVLLVGSEAF VLLDGQELTP
   361  RWTPKAAHVL RKPIFGRYKP DTLAVAVENG TGTDRQILFL DLGTGAVLCS LALPSLPGGP
   421  LSASLPTADH RSAFFFWGLH ELGSTSETET GEARHSLYMF HPTLPRVLLE LANVSTHIVA
   481  FDAVLFEPSR HAAYILLTGP ADSEAPGLVS VIKHKVRDLV PSSRVVRLGE GGPDSDQAIR
   541  DRFSRLRYQS EA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM234A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 148 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 148 nTPM
heart muscle: 103 nTPM
spinal cord: 99 nTPM
duodenum: 94 nTPM
tongue: 72 nTPM
pancreas: 64 nTPM

Single-cell type

late spermatids: 154 nCPM
enterocytes: 123 nCPM
retinal pigment epithelial cells: 90 nCPM
syncytiotrophoblasts: 89 nCPM
choroid plexus epithelial cells: 85 nCPM
colonocytes: 80 nCPM

Immune cell

myeloid DC: 18 nTPM
classical monocyte: 18 nTPM
intermediate monocyte: 18 nTPM
non-classical monocyte: 17 nTPM
NK-cell: 16 nTPM
total PBMC: 14 nTPM

Brain region

white matter: 143 nTPM
medulla oblongata: 124 nTPM
pons: 99 nTPM
choroid plexus: 86 nTPM
cerebellum: 86 nTPM
basal ganglia: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM234A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC16A2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM234A as an antibody target. Whether an autoantibody or antibody against FAM234A could matter depends on whether native FAM234A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM234A is annotated at the cell surface, where native FAM234A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FAM234A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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