Seroatlas · Human Serome Atlas

FAM229A

Protein FAM229A

Also known as: F229A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BQW9
Gene
FAM229A
Ensembl
ENSG00000225828
Chromosome
1
Canonical length
127 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM229A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>H3BQW9|FAM229A
     1  MLPSSTPGPG HATETCPAPP GPERSPAARA PAAASSLGPV STAGRAPRGL DMSAQEPPQG
    61  RRFPIEAGDS RGLAAAPESQ DSPEAVATEH NPVRPLRRCP GCHCLTLLHV PIDVYLAMGG
   121  SPRARAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM229A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
87 nTPM

Expression across tissuesHPA

Tissue

  • testis: 87 nTPM
  • liver: 9.2 nTPM
  • cerebellum: 7.9 nTPM
  • ovary: 7.7 nTPM
  • spleen: 7.7 nTPM
  • kidney: 7.2 nTPM

Single-cell type

  • late spermatids: 5,146 nCPM
  • early spermatids: 3,595 nCPM
  • late primary spermatocytes: 1,139 nCPM
  • epididymal clear cells: 43 nCPM
  • tuft cells: 35 nCPM
  • granulosa cells: 26 nCPM

Immune cell

  • MAIT T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebellum: 14 nTPM
  • medulla oblongata: 9.6 nTPM
  • basal ganglia: 8.3 nTPM
  • white matter: 8.3 nTPM
  • cerebral cortex: 8 nTPM
  • thalamus: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0.08
gnomAD missense Z
0.21
DepMap mean gene effect
-0.28
DepMap dependency class
selective

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM229A as an antibody target. Whether an autoantibody or antibody against FAM229A could matter depends on whether native FAM229A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM229A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM229A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM229A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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