FAM228B
Protein FAM228B
Also known as: F228B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0C875
- Gene
- FAM228B
- Ensembl
- ENSG00000219626
- Chromosome
- 2
- Canonical length
- 324 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus
OverviewNCBI Gene
No narrative summary is available for FAM228B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
324 residues, UniProt reviewed canonical sequence.
>P0C875|FAM228B
1 MKNVDSDDLV TGTLPKLKSS KEWLEPKPLC FMEVLAKEDT EAAIQSILYK ENSVIKELDK
61 YLQHHAFLNA RRKEMLYKRW VDCVADPLQK KIIEKVCSHK KIKKRRQGEL DGFLKHVNKK
121 GNAFIEHYDP KEYDPFYMSK KDPNFLKVTI PPFHDPLKKA QYDKDNEKRT LLQCETGKIY
181 SIKEFKEVEK VQLHSRFPQI SNSRHFITPN EWLKLPTRYI ESEFCRRRRL KVKVNFNDCS
241 FDLKPLARAP YLLESQEEEK TVIYKNKGSS FLEREPLCYQ EGNNPSAKEA ISEGYFSSLS
301 LSQEREEDQD GSPSPRLGLL KLELLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM228B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 42 nTPM
Expression across tissuesHPA
Tissue
- amygdala: 42 nTPM
- spinal cord: 40 nTPM
- midbrain: 37 nTPM
- hippocampal formation: 35 nTPM
- hypothalamus: 34 nTPM
- cerebral cortex: 33 nTPM
Single-cell type
- adipocytes: 138 nCPM
- late spermatids: 129 nCPM
- late primary spermatocytes: 99 nCPM
- epicardial cells: 93 nCPM
- early spermatids: 82 nCPM
- cardiomyocytes: 82 nCPM
Immune cell
- eosinophil: 10 nTPM
- plasmacytoid DC: 9.9 nTPM
- basophil: 9.5 nTPM
- memory B-cell: 7.4 nTPM
- myeloid DC: 6 nTPM
- naive CD8 T-cell: 5.8 nTPM
Brain region
- white matter: 58 nTPM
- cerebellum: 56 nTPM
- basal ganglia: 44 nTPM
- cerebral cortex: 44 nTPM
- hypothalamus: 43 nTPM
- spinal cord: 41 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about FAM228B.
Disease | ImmuneIEDB
Conditions an epitope on FAM228B was assayed in.
- prostate cancer B cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.28
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.81
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM228B as an antibody target. Whether an autoantibody or antibody against FAM228B could matter depends on whether native FAM228B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM228B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM228B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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