Seroatlas · Human Serome Atlas

FAM228A

Protein FAM228A

Also known as: C2orf84, F228A_HUMAN, FLJ30851

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86W67
Gene
FAM228A
Ensembl
ENSG00000186453
Chromosome
2
Canonical length
206 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for FAM228A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q86W67|FAM228A
     1  MAATKTASYD EHFRPEKLRE WPEPESVSLM EVLAREDIDE AVCAILFKEN SIVKVTVPPF
    61  VDPLFQRQQE VDEERRTGLQ CETGKRHSIK ELEEIEKARL HASSPYFTFT SHCVIPKEWH
   121  KASARARSKT YKYSPEKLIY ADKKQKRKEK KTADLSQAAF ERQFLSSKLS QKNKVGERKG
   181  LVSRGLGRGW HAGLCSTHEQ HILVPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM228A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • testis: 34 nTPM
  • adipose tissue: 2 nTPM
  • blood vessel: 1.6 nTPM
  • breast: 1.6 nTPM
  • cerebral cortex: 1.6 nTPM
  • heart muscle: 1.6 nTPM

Single-cell type

  • late primary spermatocytes: 249 nCPM
  • oocytes: 69 nCPM
  • early spermatids: 67 nCPM
  • early primary spermatocytes: 53 nCPM
  • late spermatids: 16 nCPM
  • tuft cells: 12 nCPM

Immune cell

  • plasmacytoid DC: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 10 nTPM
  • basal ganglia: 8.6 nTPM
  • white matter: 8.6 nTPM
  • cerebellum: 7.5 nTPM
  • amygdala: 7 nTPM
  • hypothalamus: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0.02
gnomAD missense Z
-0.14
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM228A as an antibody target. Whether an autoantibody or antibody against FAM228A could matter depends on whether native FAM228A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM228A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM228A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM228A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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