Seroatlas · Human Serome Atlas

FAM227B

Protein FAM227B

Also known as: C15orf33, F227B_HUMAN, FLJ32800

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M60
Gene: FAM227B
Ensembl: ENSG00000166262
Chromosome: 15
Canonical length: 508 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

No narrative summary is available for FAM227B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q96M60|FAM227B
     1  MAGQRTCQRR SSRAGPGKMQ EPPKSIEEFL KFQNWDYWPR EIHFRDDDKW SCTLKKIKED
    61  SSFVSIYTHL WENVPRIFEA LLIMESKLKE YSLILQNHTS EIFKWKSMIS ETSSYRKLER
   121  YGEFLKKYHK KKKIMLSDEM ETEKNIEGCS FTGFKANELT QLPRHLDAEQ IYLFILKAHN
   181  FDERVFKIWK THFLSEASIA LLHDSFWWWF LHKFRPDREN QDCLFDRISE SYVTLFMSIP
   241  LSRKDAFFQI YPDCLAQAIY ATFHEAFPES SYLFNDEFKE DLGNNIFLWC SGLKPQKGFW
   301  IHWKLKELST TTIHGSKKAP AKSVKERIAD SQEHISTSID FNIIKILNNP RAYTLPISKE
   361  ESRLSRLATK SHYSSTGPEF NRVLFNFGGQ SPLILYYLKM HELAGISKAP KKTKIKLTKI
   421  FQEPLPAPTY RDVIKEAKRQ FARNQKDFRI LQAKATKKPH EVKQDFEKFL HKLRSEAEIE
   481  RECVASLSSS SSSSPSSTDN YNFEEEEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM227B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

testis: 9.7 nTPM
tongue: 8.3 nTPM
ovary: 7.5 nTPM
skeletal muscle: 7.4 nTPM
retina: 7.3 nTPM
fallopian tube: 7.2 nTPM

Single-cell type

cardiomyocytes: 615 nCPM
epicardial cells: 414 nCPM
fibro-adipogenic progenitors: 353 nCPM
oocytes: 226 nCPM
myonuclei: 192 nCPM
adipocytes: 167 nCPM

Immune cell

naive CD4 T-cell: 5.8 nTPM
basophil: 5.7 nTPM
naive CD8 T-cell: 5.6 nTPM
memory CD8 T-cell: 4.6 nTPM
MAIT T-cell: 4.4 nTPM
gdT-cell: 3.4 nTPM

Brain region

white matter: 11 nTPM
medulla oblongata: 8.8 nTPM
basal ganglia: 8.3 nTPM
midbrain: 8.3 nTPM
spinal cord: 8.2 nTPM
hypothalamus: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM227B as an antibody target. Whether an autoantibody or antibody against FAM227B could matter depends on whether native FAM227B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM227B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM227B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...