Seroatlas · Human Serome Atlas

FAM227A

Protein FAM227A

Also known as: F227A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: F5H4B4
Gene: FAM227A
Ensembl: ENSG00000184949
Chromosome: 22
Canonical length: 570 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for FAM227A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>F5H4B4|FAM227A
     1  MNHFRKMEVI NLTTLPMIPV DEHLAVSLVA RNTMVKTVRK ELENNPPSCL IGSMHQVNQK
    61  IADINLRTEP SANSLAIERF ELEKKALREK TRSSPEDKVK RQRKSQYSCK GSELRHARSS
   121  VIKRKTADKN LLAELYQYSN FNSSKPNKLP NGVDFCDMVG NVVRAERDCL SGKHFCSGRE
   181  LEKFLSSSSP RAIWLDSFWW IFHERYQPNK ELQNNLFDRI AQHYALLLFR VPKSHSEEAL
   241  LKRLPSLLSK AVYTSFCCCF PQSWFDTHEF KSDICNTMSL WISGTYPSPQ SYDSWDYSEL
   301  DPERFRREEL MLYRRRLTKG REFSLFAGKR AFSQKPAQSR KFYHPQSSSA NSPSEKTSSA
   361  KQNSEKSLRM QNTAKEHHCQ TLVLKKPTQE VKRISEAREC ENMFPKKSCA ACKSPELTSN
   421  LFNIYGKSPL IVYFLQNYAS LQQHGKNVLI VRREKTTSTP DCTPTYTDVI SETLCSMKKR
   481  KDNLNQLYQH HWTEWNYFDK HLKELQDNFS REMKNIDPKA ADTKKANHMF IPPSAVNEES
   541  PDKKTKEGKG GEGKRRETEV EHFFPLTSKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM227A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 4.7 nTPM
testis: 4.7 nTPM
pituitary gland: 4 nTPM
retina: 3.3 nTPM
fallopian tube: 2.9 nTPM
epididymis: 1.8 nTPM

Single-cell type

respiratory ciliated cells: 364 nCPM
ependymal cells: 304 nCPM
choroid plexus epithelial cells: 208 nCPM
endometrial ciliated cells: 176 nCPM
early spermatids: 144 nCPM
fallopian tube ciliated cells: 137 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

choroid plexus: 20 nTPM
midbrain: 10 nTPM
medulla oblongata: 9.3 nTPM
spinal cord: 6.5 nTPM
hippocampal formation: 6.3 nTPM
hypothalamus: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 1.1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM227A as an antibody target. Whether an autoantibody or antibody against FAM227A could matter depends on whether native FAM227A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM227A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM227A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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