Seroatlas · Human Serome Atlas

FAM223B

Protein FAM223B

Also known as: F223B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKX1
Gene: FAM223B
Canonical length: 122 aa

OverviewNCBI Gene

No narrative summary is available for FAM223B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>A6NKX1|FAM223B
     1  MYVQEHRLWG LMDKPHSAPC LMSLSLSFLI CNKGRNAIRV QQSTDERMDA MLLRQCPTQG
    61  TRKNHESNSS LHHVPNWIFH STIIPPNKGS KRCLRKVDWL LPRAGGVGGK RGVTADGDRV
   121  SF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM223B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM223B as an antibody target. Whether an autoantibody or antibody against FAM223B could matter depends on whether native FAM223B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM223B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM223B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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