Seroatlas · Human Serome Atlas

FAM223A

Protein FAM223A

Also known as: F223A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWN6
Gene: FAM223A
Canonical length: 122 aa

OverviewNCBI Gene

No narrative summary is available for FAM223A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>Q8IWN6|FAM223A
     1  MYVQEHRLWG LMDKPHSAPC LMSLSLSFLI CNKGRNAIRV QQSTDERMDA MLLWQCPTQG
    61  TRKNHESNSS LHHVPNWIFH STIIPPNKGS KRCLRKVDWL LPRAGGVGGK RGVTADGDRV
   121  SF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM223A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM223A as an antibody target. Whether an autoantibody or antibody against FAM223A could matter depends on whether native FAM223A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM223A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM223A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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