Seroatlas · Human Serome Atlas

FAM222B

Protein FAM222B

Also known as: C17orf63, F222B_HUMAN, FLJ10700

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WU58
Gene: FAM222B
Ensembl: ENSG00000173065
Chromosome: 17
Canonical length: 562 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q8WU58|FAM222B
     1  MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK KVANNPLTIK
    61  IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG LLAIVKVPAK SILKDFDGTR
   121  ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ ALARQQALQH AQTLAHAPPQ TLQHPQGIPP
   181  PQALSHPQSL QQPQGLGHPQ PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP
   241  NVTVSTSTIP LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR
   301  SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS RVPTGYPSDL
   361  KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG PGFVGKAPAY PQELCLAQSF
   421  HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF QPLWNNILPT PNSDSSGSQD LAMPFHGGQP
   481  TGAPLDCAAA PGAHYRAGTG GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA
   541  PGNRAPDPTE SRSLHIQHPG YR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM222B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 32 nTPM
testis: 22 nTPM
choroid plexus: 15 nTPM
cerebellum: 12 nTPM
tongue: 12 nTPM
salivary gland: 9.9 nTPM

Single-cell type

choroid plexus epithelial cells: 327 nCPM
retinal pigment epithelial cells: 294 nCPM
cone photoreceptor cells: 232 nCPM
thymic myoid cells: 200 nCPM
myonuclei: 193 nCPM
epididymal basal cells: 186 nCPM

Immune cell

basophil: 8.3 nTPM
eosinophil: 5 nTPM
non-classical monocyte: 4.3 nTPM
naive CD4 T-cell: 4 nTPM
MAIT T-cell: 3.8 nTPM
gdT-cell: 3.5 nTPM

Brain region

choroid plexus: 40 nTPM
cerebellum: 33 nTPM
thalamus: 27 nTPM
cerebral cortex: 27 nTPM
pons: 25 nTPM
medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.29
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of FAM222B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UBQLN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM222B as an antibody target. Whether an autoantibody or antibody against FAM222B could matter depends on whether native FAM222B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM222B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM222B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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