FAM222A
Protein FAM222A
Also known as: C12orf34, F222A_HUMAN, FLJ14721
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5U5X8
- Gene
- FAM222A
- Ensembl
- ENSG00000139438
- Chromosome
- 12
- Canonical length
- 452 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Cell Junctions,Midbody ring
OverviewNCBI Gene
No narrative summary is available for FAM222A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
452 residues, UniProt reviewed canonical sequence.
>Q5U5X8|FAM222A
1 MLACLQRTQN APGQHLACPS KSLELRKCEA VASAMHSSRY PSPAELDAYA EKVANSPLSI
61 KIFPTNIRVP QHKHLSRTVN GYDTSGQRYS PYPQHTAGYQ GLLAIVKAAV SSSSTAAPAG
121 PAKSVLKSAE GKRTKLSPAA VQVGIAPYPV PSTLGPLAYP KPPEAPAPPP GLPAAATAAS
181 VIPLPGRGLP LPPSNLPSIH SLLYQLNQQC QAPGAAPPAC QGMAIPHPSP AKHGPVPSFP
241 SMAYSAAAGL PDCRKGTELG QGATQALTLA GAAKPAGYAD SGLDYLLWPQ KPPPPPPQPL
301 RAYSGSTVAS KSPEACGGRA YERASGSPLN CGVGLPTSFT VGQYFAAPWN SVLVTPTSDC
361 YNPAAAVVVT ELGPGAAREL AGPPADALSG LPSKSVCNTS VLSSSLQSLE YLINDIRPPC
421 IKEQMLGKGY ETVAVPRLLD HQHAHIRLPV YRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM222A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.72
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 50 nTPM
- midbrain: 27 nTPM
- testis: 23 nTPM
- pituitary gland: 22 nTPM
- basal ganglia: 21 nTPM
- retina: 21 nTPM
Single-cell type
- rod photoreceptor cells: 186 nCPM
- early spermatids: 172 nCPM
- retinal horizontal cells: 140 nCPM
- late spermatids: 118 nCPM
- oligodendrocytes: 107 nCPM
- cone photoreceptor cells: 89 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 126 nTPM
- thalamus: 95 nTPM
- basal ganglia: 87 nTPM
- midbrain: 84 nTPM
- medulla oblongata: 81 nTPM
- cerebral cortex: 74 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about FAM222A.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 112 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.45
- gnomAD pLI
- 0.85
- gnomAD missense Z
- 1.12
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM222A as an antibody target. Whether an autoantibody or antibody against FAM222A could matter depends on whether native FAM222A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM222A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM222A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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