Seroatlas · Human Serome Atlas

FAM221B

Protein FAM221B

Also known as: C9orf128, F221B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6H8Z2
Gene: FAM221B
Ensembl: ENSG00000204930
Chromosome: 9
Canonical length: 402 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM221B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>A6H8Z2|FAM221B
     1  MEAHEIIEEP HITMDAEKHP PSKDPSAEDL QENHISESFL KPSTSETPLE PHTSESPLVP
    61  SPSQIPLEAH SPETHQEPSI SETPSETPTY EASLDSPISV VPEKHLTLPP QSRDYVCLSS
   121  SDTLKEDLSS ESSSNEVPWT RRSTHLSESE SLPEHCLSGP SSQVQVDTTE KQEEEAGEVE
   181  KGVDASDSTA HTAQPGHQLG NTARPVFPAR QTELVEVAKA MHREEFGAQV NNLFQWEKDA
   241  ALNAIQTGLY IGWRCPHYLW DCFRIGDESR CFCGHLLREH RIISDISVPC KVSQCRCFMF
   301  CFIPSRPEEV GEFWLKRRAT FDPKAWRAQC RCKHSHEEHA ATGPHPCRHH GCCCGCFESN
   361  FLCAACDRRW EEHETFFDTQ KTRQRGGRPR GTDTVSNWHR PL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM221B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

testis: 8.3 nTPM
bone marrow: 2.7 nTPM
prostate: 0.7 nTPM
salivary gland: 0.7 nTPM
lymph node: 0.5 nTPM
rectum: 0.5 nTPM

Single-cell type

early spermatids: 243 nCPM
late spermatids: 125 nCPM
late primary spermatocytes: 83 nCPM
epididymal efferent duct ciliated cells: 2.5 nCPM
pdcs: 2 nCPM
renal collecting duct intercalated cells: 1.8 nCPM

Immune cell

plasmacytoid DC: 2.8 nTPM
neutrophil: 0.9 nTPM
basophil: 0.4 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM

Brain region

cerebellum: 4.4 nTPM
medulla oblongata: 2.9 nTPM
white matter: 2.9 nTPM
pons: 2.8 nTPM
cerebral cortex: 2.4 nTPM
spinal cord: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM221B as an antibody target. Whether an autoantibody or antibody against FAM221B could matter depends on whether native FAM221B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM221B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM221B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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