FAM221A
Protein FAM221A
Also known as: C7orf46, DKFZp686F0810, F221A_HUMAN, FLJ45875, MGC72075
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A4D161
- Gene
- FAM221A
- Ensembl
- ENSG00000188732
- Chromosome
- 7
- Canonical length
- 298 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
No narrative summary is available for FAM221A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
298 residues, UniProt reviewed canonical sequence.
>A4D161|FAM221A
1 MERLTLPLGG AAAVDEYLEY RRIVGEDDGG KLFTPEEYEE YKRKVLPLRL QNRLFVSWRS
61 PTGMDCKLVG PETLCFCTHR YKQHKTDLEA IPQQCPIDLP CQVTGCQCRA YLYVPLNGSQ
121 PIRCRCKHFA DQHSAAPGFT CNTCSKCSGF HSCFTCACGQ PAYAHDTVVE TKQERLAQEK
181 PVGQDIPYAA MGGLTGFSSL AEGYMRLDDS GIGVPSVEFL ESPITAVDSP FLKAFQASSS
241 SSPETLTDVG TSSQVSSLRR PEEDDMAFFE RRYQERMKME KAAKWKGKAP LPSATKPSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM221A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 30 nTPM
- pancreas: 19 nTPM
- midbrain: 19 nTPM
- testis: 18 nTPM
- hippocampal formation: 17 nTPM
- hypothalamus: 16 nTPM
Single-cell type
- retinal pigment epithelial cells: 252 nCPM
- sertoli cells: 104 nCPM
- oligodendrocytes: 98 nCPM
- esophageal apical cells: 89 nCPM
- choroid plexus epithelial cells: 58 nCPM
- gastric chief cells: 57 nCPM
Immune cell
- T-reg: 12 nTPM
- MAIT T-cell: 11 nTPM
- naive CD4 T-cell: 9.8 nTPM
- memory CD4 T-cell: 8.6 nTPM
- NK-cell: 7.8 nTPM
- naive B-cell: 6.9 nTPM
Brain region
- white matter: 24 nTPM
- cerebellum: 14 nTPM
- pons: 13 nTPM
- medulla oblongata: 13 nTPM
- basal ganglia: 11 nTPM
- spinal cord: 10 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.66
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.34
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM221A as an antibody target. Whether an autoantibody or antibody against FAM221A could matter depends on whether native FAM221A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM221A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM221A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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