Seroatlas · Human Serome Atlas

FAM220BP

Putative protein FAM220BP

Also known as: F220P_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B1ANY3
Gene: FAM220BP
Canonical length: 271 aa

OverviewNCBI Gene

No narrative summary is available for FAM220BP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>B1ANY3|FAM220BP
     1  MRDRRGPLGT CLAQVQWAGG GDSDKLSYSL KKRMPTEGPW PADAPSWMNK PAVDGNSQSE
    61  ALSLEMAGLS LPSGGPVLPY VKESARRNPA SAATPSAAVG LFPAPTEYFA RVSCSGVEAL
   121  GRDWLGGGPR ATHGHRGQCP KGEPRVSRLT RHQKLPEMGS FWDDPPSAFP SGLGSELEPS
   181  CLHSILSATL HACPEVLLKD ETKRIFLDLL NPMFSKQTIE FKKMFKSTSD GLQITLGLLA
   241  LQHFELANSL CHSLKYKQNN ASRLILRVVL E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM220BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM220BP as an antibody target. Whether an autoantibody or antibody against FAM220BP could matter depends on whether native FAM220BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM220BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM220BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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