Seroatlas · Human Serome Atlas

FAM219B

Protein FAM219B

Also known as: C15orf17, F219B_HUMAN, FLJ00005

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5XKK7
Gene
FAM219B
Ensembl
ENSG00000178761
Chromosome
15
Canonical length
198 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for FAM219B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q5XKK7|FAM219B
     1  MATAEPSGRA LRLSTPGPRP SGARDRAPGA AGPPSGQIGN RALRLGERTP AAVEKRGPYM
    61  VTRAPSIQAK LQKHRDLAKA VLRRKGMLGA SPNRPDSSGK RSVKFNKGYT ALSQSPDENL
   121  VSLDSDSDGE LGSRYSSGYS SAEQVNQDVS RQLLQDGYHL DEIPDDEDLD LIPPKPMASS
   181  TCSCCWCCLG DSSSCTLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM219B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • retina: 41 nTPM
  • choroid plexus: 39 nTPM
  • heart muscle: 36 nTPM
  • esophagus: 36 nTPM
  • pituitary gland: 36 nTPM
  • spleen: 33 nTPM

Single-cell type

  • esophageal apical cells: 225 nCPM
  • adrenal medulla cells: 64 nCPM
  • cardiomyocytes: 64 nCPM
  • esophageal suprabasal cells: 63 nCPM
  • adipocytes: 59 nCPM
  • rod photoreceptor cells: 39 nCPM

Immune cell

  • eosinophil: 7 nTPM
  • basophil: 3.9 nTPM
  • MAIT T-cell: 2.4 nTPM
  • memory B-cell: 2.2 nTPM
  • memory CD4 T-cell: 2.1 nTPM
  • naive B-cell: 2 nTPM

Brain region

  • hypothalamus: 39 nTPM
  • pons: 37 nTPM
  • thalamus: 35 nTPM
  • midbrain: 34 nTPM
  • medulla oblongata: 32 nTPM
  • choroid plexus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM219B as an antibody target. Whether an autoantibody or antibody against FAM219B could matter depends on whether native FAM219B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM219B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM219B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM219B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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