FAM219A
Protein FAM219A
Also known as: bA573M23.5, C9orf25, F219A_HUMAN, FLJ39031
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IW50
- Gene
- FAM219A
- Ensembl
- ENSG00000164970
- Chromosome
- 9
- Canonical length
- 185 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Golgi apparatus,Vesicles
OverviewNCBI Gene
The protein encoded by this gene has homologs that have been identified in mouse, macaque, etc organisms. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Canonical amino-acid sequenceUniProt
185 residues, UniProt reviewed canonical sequence.
>Q8IW50|FAM219A
1 MMEEIDRFQV PTAHSEMQPL DPAAASISDG DCDAREGESV AMNYKPSPLQ VKLEKQRELA
61 RKGSLKNGSM GSPVNQQPKK NNVMARTRLV VPNKGYSSLD QSPDEKPLVA LDTDSDDDFD
121 MSRYSSSGYS SAEQINQDLN IQLLKDGYRL DEIPDDEDLD LIPPKSVNPT CMCCQATSST
181 ACHIQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM219A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 74 nTPM
Expression across tissuesHPA
Tissue
- midbrain: 74 nTPM
- spinal cord: 66 nTPM
- cerebral cortex: 65 nTPM
- hypothalamus: 63 nTPM
- amygdala: 61 nTPM
- basal ganglia: 61 nTPM
Single-cell type
- myonuclei: 101 nCPM
- retinal ganglion cells: 100 nCPM
- cardiomyocytes: 89 nCPM
- lactotrophs: 85 nCPM
- somatotrophs: 83 nCPM
- retinal horizontal cells: 74 nCPM
Immune cell
- eosinophil: 1.1 nTPM
- basophil: 0.6 nTPM
- neutrophil: 0.5 nTPM
- T-reg: 0.4 nTPM
- gdT-cell: 0.3 nTPM
- MAIT T-cell: 0.2 nTPM
Brain region
- pons: 173 nTPM
- medulla oblongata: 162 nTPM
- cerebral cortex: 153 nTPM
- midbrain: 153 nTPM
- spinal cord: 150 nTPM
- white matter: 146 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.77
- gnomAD pLI
- 0.15
- gnomAD missense Z
- 2.18
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FAM219A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM219A as an antibody target. Whether an autoantibody or antibody against FAM219A could matter depends on whether native FAM219A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM219A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM219A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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