Seroatlas · Human Serome Atlas

FAM218A

Protein FAM218A

Also known as: F218A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MZ4
Gene: FAM218A
Canonical length: 157 aa

OverviewNCBI Gene

No narrative summary is available for FAM218A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>Q96MZ4|FAM218A
     1  MEGCAVRRGS CPLLPGPSAW RASPAGWAGR AKLRSWCRAS GLPNRPYTLT GGRHGSVSLL
    61  RHPGTTTFVQ QRSLHQSWEK RIVFSACPVS RSWCPERNFS GSIPAVTPPK LPGHSKSEGP
   121  PGKVRKRTTI RSQPLFVTRT RGFGSAVGWL PLGSPVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM218A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.23

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM218A as an antibody target. Whether an autoantibody or antibody against FAM218A could matter depends on whether native FAM218A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM218A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM218A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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