Seroatlas · Human Serome Atlas

FAM217B

Protein FAM217B

Also known as: C20orf177, dJ551D2.5, F217B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NTX9
Gene: FAM217B
Ensembl: ENSG00000196227
Chromosome: 20
Canonical length: 383 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q9NTX9|FAM217B
     1  MNAGPSWNKV QHSKNSSGKR QSKSQVPHAS SQPRSSLTAV TQPTEEKLKE SISPEARRKR
    61  NPLGSRCQGA SGNKLFLDFQ SMKIIKENAD EDSASDLSDS ERIPIPPSPL TPPDLNLRAE
   121  EIDPVYFDLH PGQGHTKPEY YYPNFLPSPF SSWDLRDMAL LLNAENKTEA VPRVGGLLGK
   181  YIDRLIQLEW LQVQTVQCEK AKGGKARPPT APGTSGALKS PGRSKLIASA LSKPLPHQEG
   241  ASKSGPSRKK AFHHEEIHPS HYAFETSPRP IDVLGGTRFC SQRQTLEMRT EEKKKKSSKS
   301  TKLQRWDLSG SGSSSKVETS GHIRVPKQAA VILDSADSCK ASKTQAHAHP RKKGKAESCG
   361  HATVSSEKKL KTNGVKQNTY KLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM217B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 19 nTPM
tongue: 16 nTPM
skeletal muscle: 15 nTPM
bone marrow: 13 nTPM
cerebellum: 11 nTPM
amygdala: 11 nTPM

Single-cell type

neutrophil progenitors: 109 nCPM
neutrophils: 108 nCPM
tuft cells: 81 nCPM
megakaryocytes: 68 nCPM
cardiomyocytes: 54 nCPM
late primary spermatocytes: 53 nCPM

Immune cell

neutrophil: 11 nTPM
MAIT T-cell: 10 nTPM
basophil: 9.3 nTPM
naive CD8 T-cell: 8.8 nTPM
gdT-cell: 8.5 nTPM
eosinophil: 8.3 nTPM

Brain region

cerebral cortex: 51 nTPM
white matter: 41 nTPM
basal ganglia: 34 nTPM
thalamus: 32 nTPM
midbrain: 31 nTPM
hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.11
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM217B as an antibody target. Whether an autoantibody or antibody against FAM217B could matter depends on whether native FAM217B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM217B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM217B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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