Seroatlas · Human Serome Atlas

FAM217A

Protein FAM217A

Also known as: C6orf146, F217A_HUMAN, MGC43581

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXS0
Gene: FAM217A
Ensembl: ENSG00000145975
Chromosome: 6
Canonical length: 508 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM217A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q8IXS0|FAM217A
     1  MGRRNENCAN SLRVSNISQE NLSHWNLDSE VPVSENKNLP AGRDGAAGGK INKNYLEIPV
    61  EQLMLEPNLS VHSQKSTQNS KQGIFQLWNC PLNEGSTIEK REFKKSSVET GFNVINHPIR
   121  VFTLNHPLTI ASVDKQVGPY PGLPMPLGLC WPYADGDFFK NRNEIHVSSC STIENNDGET
   181  LPAPNWNLKH GNSSVEENFT DESDLSENEK TNDTLLSYFK KVDLNLKPET IKNVEEPFTE
   241  EPNEVFPYPD FLPPPFSALD LHNLALSKSD NWKVTVDPAE TSVEHLITRL LELERLQHMT
   301  IQKERPRLQT TFCTPAVTER PSSSKATPKV RQPKLCDSLS LQIPCVDKSQ EKSKNNSGSC
   361  KLEQNALKRN WSNAGKYRWN SRPLSLKSSS TPKQLIETYD KNPKSSILSP CQELSFKPTI
   421  GHTNQSMVKM VSTRCLPWRS PMPVSPIPLT FPENQKEEIK APKRNFGTKK KLYRQNIVLN
   481  RPFSIQKLNC LSPSLIAKDK CCSPIEQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM217A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
pancreas: 1.5 nTPM
epididymis: 0.5 nTPM
kidney: 0.3 nTPM
cervix: 0.1 nTPM
gallbladder: 0.1 nTPM

Single-cell type

late spermatids: 704 nCPM
cardiomyocytes: 218 nCPM
early spermatids: 214 nCPM
late primary spermatocytes: 206 nCPM
epicardial cells: 196 nCPM
adipocytes: 72 nCPM

Immune cell

gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
midbrain: 0.1 nTPM
pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM217A as an antibody target. Whether an autoantibody or antibody against FAM217A could matter depends on whether native FAM217A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM217A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM217A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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