Seroatlas · Human Serome Atlas

FAM216B

Protein FAM216B

Also known as: C13orf30, F216B_HUMAN, FLJ40919

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N7L0
Gene
FAM216B
Ensembl
ENSG00000179813
Chromosome
13
Canonical length
139 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for FAM216B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>Q8N7L0|FAM216B
     1  MGQNWKRQQK LWNVPQLPFI RVPPSIYDTS LLKALNQGQQ RYFYSIMRIY NSRPQWEALQ
    61  TRYIHSLQHQ QLLGYITQRE ALSYALVLRD STKRASAKVA PQRTIPRKTS AMTRRCPSVL
   121  PVSVVLPRAQ SKRRQVLRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM216B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 73 nTPM
  • heart muscle: 9.4 nTPM
  • lung: 9.3 nTPM
  • choroid plexus: 4.7 nTPM
  • tonsil: 3.3 nTPM
  • basal ganglia: 2.1 nTPM

Single-cell type

  • respiratory ciliated cells: 409 nCPM
  • fallopian tube ciliated cells: 271 nCPM
  • endometrial ciliated cells: 190 nCPM
  • epididymal efferent duct ciliated cells: 167 nCPM
  • ependymal cells: 82 nCPM
  • late spermatids: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 21 nTPM
  • midbrain: 20 nTPM
  • spinal cord: 15 nTPM
  • choroid plexus: 12 nTPM
  • white matter: 7.8 nTPM
  • pons: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM216B as an antibody target. Whether an autoantibody or antibody against FAM216B could matter depends on whether native FAM216B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM216B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM216B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM216B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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