FAM216A
Protein FAM216A
Also known as: C12orf24, F216A_HUMAN, HSU79274
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WUB2
- Gene
- FAM216A
- Ensembl
- ENSG00000204856
- Chromosome
- 12
- Canonical length
- 273 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Actin filaments
OverviewNCBI Gene
No narrative summary is available for FAM216A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
273 residues, UniProt reviewed canonical sequence.
>Q8WUB2|FAM216A
1 MLGQLLPHTA RGLGAAEMPG QGPGSDWTER SSSAEPPAVA GTEGGGGGSA GYSCYQNSKG
61 SDRIKDGYKV NSHIAKLQEL WKTPQNQTIH LSKSMMEASF FKHPDLTTGQ KRYLCSIAKI
121 YNANYLKMLM KRQYMHVLQH SSQKPGVLTH HRSRLSSRYS QKQHYPCTTW RHQLEREDSG
181 SSDIAAASAP EMLIQHSLWR PVRNKEGIKT GYASKTRCKS LKIFRRPRKL FMQTVSSDDS
241 ESHMSEEKKE EDLLNNFMQS MSIEEQGEHL MLTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM216A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 56 nTPM
Expression across tissuesHPA
Tissue
- testis: 56 nTPM
- cerebral cortex: 30 nTPM
- cerebellum: 27 nTPM
- hypothalamus: 26 nTPM
- hippocampal formation: 19 nTPM
- basal ganglia: 18 nTPM
Single-cell type
- late primary spermatocytes: 287 nCPM
- early primary spermatocytes: 154 nCPM
- late spermatids: 78 nCPM
- megakaryocyte-erythroid progenitors: 42 nCPM
- early spermatids: 35 nCPM
- microglia: 35 nCPM
Immune cell
- naive CD4 T-cell: 9.4 nTPM
- naive B-cell: 8.3 nTPM
- memory B-cell: 7.3 nTPM
- naive CD8 T-cell: 5.7 nTPM
- myeloid DC: 4.5 nTPM
- total PBMC: 3.9 nTPM
Brain region
- cerebral cortex: 27 nTPM
- hypothalamus: 20 nTPM
- cerebellum: 20 nTPM
- pons: 15 nTPM
- medulla oblongata: 15 nTPM
- thalamus: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.72
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0.17
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM216A as an antibody target. Whether an autoantibody or antibody against FAM216A could matter depends on whether native FAM216A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM216A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM216A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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