Seroatlas · Human Serome Atlas

FAM215A

Uncharacterized protein FAM215A

Also known as: F215A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5M1
Gene: FAM215A
Canonical length: 114 aa

OverviewNCBI Gene

No narrative summary is available for FAM215A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>Q9Y5M1|FAM215A
     1  MVSLWVEGTF PPPGFGLAHV ACSGHGMKQK RKPASSEPTP EDALGGSAVP VRFHLHPEGL
    61  LWCSRCFFSH GPKGSEPPGR SAGLQGATER SGRPSVQAQA QACENLVPAT VWDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM215A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.56

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM215A as an antibody target. Whether an autoantibody or antibody against FAM215A could matter depends on whether native FAM215A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM215A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM215A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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