Seroatlas · Human Serome Atlas

FAM210B

Protein FAM210B, mitochondrial

Also known as: C20orf108, dJ1167H4.1, DKFZP434A1114, F210B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KR6
Gene: FAM210B
Ensembl: ENSG00000124098
Chromosome: 20
Canonical length: 192 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in cellular response to estradiol stimulus and positive regulation of erythrocyte differentiation. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q96KR6|FAM210B
     1  MAGLLALLGP AGRVGARVRP RATWLLGATA PCAPPPLALA LLPPRLDARL LRTARGDCRG
    61  HQDPSQATGT TGSSVSCTEE KKQSKSQQLK KIFQEYGTVG VSLHIGISLI SLGIFYMVVS
   121  SGVDMPAILL KLGFKESLVQ SKMAAGTSTF VVAYAIHKLF APVRISITLV SVPLIVRYFR
   181  KVGFFKPPAA KP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM210B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

tongue: 95 nTPM
liver: 94 nTPM
ovary: 90 nTPM
adrenal gland: 84 nTPM
bone marrow: 80 nTPM
skeletal muscle: 71 nTPM

Single-cell type

erythrocytes: 276 nCPM
erythrocyte progenitors: 251 nCPM
hepatocytes: 176 nCPM
peritubular myoid cells: 146 nCPM
respiratory ionocytes: 145 nCPM
prostatic glandular cells: 140 nCPM

Immune cell

eosinophil: 6.9 nTPM
intermediate monocyte: 3.3 nTPM
basophil: 2.3 nTPM
classical monocyte: 2.3 nTPM
memory CD8 T-cell: 2.3 nTPM
T-reg: 2.3 nTPM

Brain region

choroid plexus: 48 nTPM
thalamus: 44 nTPM
midbrain: 40 nTPM
basal ganglia: 40 nTPM
hippocampal formation: 40 nTPM
hypothalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0.09
gnomAD missense Z: 0.85
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM210B as an antibody target. Whether an autoantibody or antibody against FAM210B could matter depends on whether native FAM210B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM210B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM210B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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