FAM209A
Protein FAM209A
Also known as: C20orf106, dJ1153D9.3, F209A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5JX71
- Gene
- FAM209A
- Ensembl
- ENSG00000124103
- Chromosome
- 20
- Canonical length
- 171 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Plasma membrane,Cell Junctions
OverviewNCBI Gene
Predicted to be involved in cell differentiation and spermatogenesis. Located in extracellular exosome and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
171 residues, UniProt reviewed canonical sequence.
>Q5JX71|FAM209A
1 MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVQYGE HFRIRQNLPE HTQGWLGSKW
61 LWLLFVVVPF VILQCQRDSE KNKEQSPPGL RGGQLHSPLK KKRNASPNKD CAFNTLMELE
121 VELMKFVSKV RNLKRAMATG SGSNLRLRKS EMPADPYHVT ICEIWGEESS SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM209A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 151 nTPM
Expression across tissuesHPA
Tissue
- testis: 151 nTPM
- bone marrow: 16 nTPM
- spleen: 2.2 nTPM
- lymph node: 1.4 nTPM
- tonsil: 1.2 nTPM
- skin: 1.1 nTPM
Single-cell type
- early spermatids: 2,793 nCPM
- late primary spermatocytes: 681 nCPM
- late spermatids: 267 nCPM
- neutrophils: 42 nCPM
- neutrophil progenitors: 14 nCPM
- sertoli cells: 6.5 nCPM
Immune cell
- neutrophil: 0.6 nTPM
- gdT-cell: 0.4 nTPM
- memory B-cell: 0.4 nTPM
- eosinophil: 0.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- cerebral cortex: 0.8 nTPM
- basal ganglia: 0.4 nTPM
- cerebellum: 0.4 nTPM
- hippocampal formation: 0.4 nTPM
- pons: 0.4 nTPM
- thalamus: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.42
- gnomAD pLI
- 0.08
- gnomAD missense Z
- -0.34
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FAM209A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM209A as an antibody target. Whether an autoantibody or antibody against FAM209A could matter depends on whether native FAM209A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM209A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM209A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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