Seroatlas · Human Serome Atlas

FAM204A

Protein FAM204A

Also known as: bA319I23.1, C10orf84, F204A_HUMAN, FLJ13188

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8W3
Gene: FAM204A
Ensembl: ENSG00000165669
Chromosome: 10
Canonical length: 233 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

No narrative summary is available for FAM204A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q9H8W3|FAM204A
     1  MWSGLLPPGL NESDAESNSE DEATLENSGL NLQEDKEDES IRKTEIIDFS TDEPKTETES
    61  NVNAYEECPS GIPIDMWNKF QELHKKHSEQ KSTTSRFRGK RRKRSRKDKL KNEKELHSEP
   121  SSNETQWKEL TQYFGVNDRF DPPVKRKKVE KSGLEKRIDQ AVEEWNIEKA EELSNQLATR
   181  ELGVKIAKAV ACHNFVKAKK EVENSQAARK KKKLAWGFEA KKRWETKSNM GYM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM204A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 51 nTPM
testis: 46 nTPM
skeletal muscle: 35 nTPM
heart muscle: 33 nTPM
blood vessel: 31 nTPM
epididymis: 31 nTPM

Single-cell type

late primary spermatocytes: 345 nCPM
megakaryocytes: 266 nCPM
early spermatids: 248 nCPM
early primary spermatocytes: 226 nCPM
differentiating spermatogonia: 180 nCPM
late spermatids: 168 nCPM

Immune cell

basophil: 74 nTPM
eosinophil: 71 nTPM
non-classical monocyte: 70 nTPM
intermediate monocyte: 64 nTPM
myeloid DC: 60 nTPM
classical monocyte: 58 nTPM

Brain region

cerebral cortex: 26 nTPM
basal ganglia: 24 nTPM
hippocampal formation: 24 nTPM
hypothalamus: 23 nTPM
medulla oblongata: 22 nTPM
white matter: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.01
gnomAD missense Z: 0.99
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein FAM204A

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of FAM204A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SMYD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM204A as an antibody target. Whether an autoantibody or antibody against FAM204A could matter depends on whether native FAM204A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM204A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM204A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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