Seroatlas · Human Serome Atlas

FAM193B

Protein FAM193B

Also known as: F193B_HUMAN, FLJ10404, IRIZIO, KIAA1931

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PV7
Gene: FAM193B
Ensembl: ENSG00000146067
Chromosome: 5
Canonical length: 902 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Located in cytoplasm; nuclear speck; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

902 residues, UniProt reviewed canonical sequence.

>Q96PV7|FAM193B
     1  MTRRRSRPSG GAGRRERARA AGPQKPQAPE PPPPPSLEAG AGAGPPEAPA EPDHDGPRED
    61  DEPNLVPGPQ VPPASSQPVQ TCCLLCHRER KGWEEGPSQN GLVLQGEKLP PDFMPKLVKN
   121  LLGEMPLWVC QSCRKSMEED ERQTGREHAV AISLSHTSCK SQSCGDDSHS SSSSSSSSSS
   181  SSSSSCPGNS GDWDPSSFLS AHKLSGLWNS PHSSGAMPGS SLGSPPTIPG EAFPVSEHHQ
   241  HSDLTAPPNS PTGHHPQPAS LIPSHPSSFG SPPHPHLLPT TPAAPFPAQA SECPVAAATA
   301  PHTPGPCQSS HLPSTSMPLL KMPPPFSGCS HPCSGHCGGH CSGPLLPPPS SQPLPSTHRD
   361  PGCKGHKFAH SGLACQLPQP CEADEGLGEE EDSSSERSSC TSSSTHQRDG KFCDCCYCEF
   421  FGHNAPPAAP TSRNYTEIRE KLRSRLTRRK EELPMKGGTL GGIPGEPAVD HRDVDELLEF
   481  INSTEPKVPN SARAAKRARH KLKKKEKEKA QLAAEALKQA NRVSGSREPR PARERLLEWP
   541  DRELDRVNSF LSSRLQEIKN TVKDSIRASF SVCELSMDSN GFSKEGAAEP EPQSLPPSNL
   601  SGSSEQQPDI NLDLSPLTLG SPQNHTLQAP GEPAPPWAEM RGPHPPWTEV RGPPPGIVPE
   661  NGLVRRLNTV PNLSRVIWVK TPKPGYPSSE EPSSKEVPSC KQELPEPVSS GGKPQKGKRQ
   721  GSQAKKSEAS PAPRPPASLE VPSAKGQVAG PKQPGRVLEL PKVGSCAEAG EGSRGSRPGP
   781  GWAGSPKTEK EKGSSWRNWP GEAKARPQEQ ESVQPSGPAR PQSLPQGKGR SRRSRNKQEK
   841  PASSLDDVFL PKDMDGVEMD ETDREVEYFK RFCLDSAKQT RQKVAVNWTN FSLKKTTPST
   901  AQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM193B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

spleen: 67 nTPM
skin: 53 nTPM
bone marrow: 51 nTPM
pancreas: 50 nTPM
liver: 49 nTPM
ovary: 49 nTPM

Single-cell type

neutrophils: 97 nCPM
choroid plexus epithelial cells: 92 nCPM
myonuclei: 81 nCPM
adrenal cortex cells: 75 nCPM
proximal tubule cells: 68 nCPM
podocytes: 67 nCPM

Immune cell

gdT-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
neutrophil: 0.2 nTPM

Brain region

thalamus: 63 nTPM
cerebral cortex: 57 nTPM
hippocampal formation: 54 nTPM
amygdala: 53 nTPM
cerebellum: 50 nTPM
hypothalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 0.83
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM193B as an antibody target. Whether an autoantibody or antibody against FAM193B could matter depends on whether native FAM193B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM193B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM193B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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