Seroatlas · Human Serome Atlas

FAM193A

Protein FAM193A

Also known as: C4orf8, F193A_HUMAN, RES4-22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78312
Gene: FAM193A
Ensembl: ENSG00000125386
Chromosome: 4
Canonical length: 1265 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for FAM193A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1265 residues, UniProt reviewed canonical sequence.

>P78312|FAM193A
     1  MKVRLLRQLS AAAKVKAPSG LQGPPQAHQF ISLLLEEYGA LCQAARSIST FLGTLENEHL
    61  KKFQVTWELH NKHLFENLVF SEPLLQSNLP ALVSQIRLGT TTHDTCSEDT YSTLLQRYQR
   121  SEEELRRVAE EWLECQKRID AYVDEQMTMK TKQRMLTEDW ELFKQRRFIE EQLTNKKAVT
   181  GENNFTDTMR HMLSSRLSMP DCPNCNYRRR CACDDCSLSH ILTCGIMDPP VTDDIHIHQL
   241  PLQVDPAPDY LAERSPPSVS SASSGSGSSS PITIQQHPRL ILTDSGSAPT FCSDDEDVAP
   301  LSAKFADIYP LSNYDDTEVV ANMNGIHSEL NGGGENMALK DESPQISSTS SSSSEADDEE
   361  ADGESSGEPP GAPKEDGVLG SRSPRTEESK ADSPPPSYPT QQAEQAPNTC ECHVCKQEAS
   421  GLTPSAMTAG ALPPGHQFLS PEKPTHPALH LYPHIHGHVP LHTVPHLPRP LIHPTLYATP
   481  PFTHSKALPP APVQNHTNKH QVFNASLQDH IYPSCFGNTP EWNSSKFISL WGSEVMNDKN
   541  WNPGTFLPDT ISGSEILGPT LSETRPEALP PPSSNETPAV SDSKEKKNAA KKKCLYNFQD
   601  AFMEANKVVM ATSSATSSVS CTATTVQSSN SQFRVSSKRP PSVGDVFHGI SKEDHRHSAP
   661  AAPRNSPTGL APLPALSPAA LSPAALSPAS TPHLANLAAP SFPKTATTTP GFVDTRKSFC
   721  PAPLPPATDG SISAPPSVCS DPDCEGHRCE NGVYDPQQDD GDESADEDSC SEHSSSTSTS
   781  TNQKEGKYCD CCYCEFFGHG GPPAAPTSRN YAEMREKLRL RLTKRKEEQP KKMDQISERE
   841  SVVDHRRVED LLQFINSSET KPVSSTRAAK RARHKQRKLE EKARLEAEAR AREHLHLQEE
   901  QRRREEEEDE EEEEDRFKEE FQRLQELQKL RAVKKKKKER PSKDCPKLDM LTRNFQAATE
   961  SVPNSGNIHN GSLEQTEEPE TSSHSPSRHM NHSEPRPGLG ADGDAADPVD TRDSKFLLPK
  1021  EVNGKQHEPL SFFFDIMQHH KEGNGKQKLR QTSKASSEPA RRPTEPPKAT EGQSKPRAQT
  1081  ESKAKVVDLM SITEQKREER KVNSNNNNKK QLNHIKDEKS NPTPMEPTSP GEHQQNSKLV
  1141  LAESPQPKGK NKKNKKKKGD RVNNSIDGVS LLLPSLGYNG AILAHCNLRL PGSSDCAASA
  1201  SQVVGITDDV FLPKDIDLDS VDMDETEREV EYFKRFCLDS ARQTRQRLSI NWSNFSLKKA
  1261  TFAAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM193A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
cerebellum: 18 nTPM
pituitary gland: 15 nTPM
ovary: 14 nTPM
cervix: 14 nTPM
skeletal muscle: 14 nTPM

Single-cell type

myonuclei: 218 nCPM
neutrophils: 196 nCPM
sertoli cells: 173 nCPM
gonadotrophs: 172 nCPM
somatotrophs: 160 nCPM
choroid plexus epithelial cells: 157 nCPM

Immune cell

basophil: 3.3 nTPM
non-classical monocyte: 3.1 nTPM
neutrophil: 1.8 nTPM
plasmacytoid DC: 1.7 nTPM
NK-cell: 1.3 nTPM
memory CD8 T-cell: 1.2 nTPM

Brain region

cerebellum: 44 nTPM
cerebral cortex: 39 nTPM
white matter: 37 nTPM
thalamus: 34 nTPM
medulla oblongata: 34 nTPM
choroid plexus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 0.91
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM193A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM193A as an antibody target. Whether an autoantibody or antibody against FAM193A could matter depends on whether native FAM193A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM193A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM193A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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