Seroatlas · Human Serome Atlas

FAM187B

Protein FAM187B

Also known as: F187B_HUMAN, FLJ25660, TMEM162

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17R55
Gene: FAM187B
Ensembl: ENSG00000177558
Chromosome: 19
Canonical length: 369 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q17R55|FAM187B
     1  MPPMLWLLLH FAAPALGFYF SISCPSGKQC QQALLSGNDI LLYCNSSGAH WYYLFTQGKK
    61  GRLTSLTNIS NMEIMPEGSL LIKDPLPSQT GLYHCWNKNG RQVVQYEIDF QDVTTLHITH
   121  KDLGQRPLQN ETLHLGSKQL IFTWWEPWQD CNRCEEPGEC KRLGYRYIEE PLEEAMPCWL
   181  YLGEVLVWSS RLRPELQVEA CHVQCTNNTQ LRVDYVIFDN FRLDEKTEFV WLDCPLGSMY
   241  RPVNWRANDT PLTWESQLSG QDFTTFLDPS TGGRQLQVFQ PAVYKCFVQQ ELVAQFKPAA
   301  SLETLEAQWR ENDAQWREAR KALRGRADSV LKGLKLVLLV VTVLALLGAL LKCIHPSPGR
   361  RSTQVLVVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM187B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

testis: 65 nTPM
spleen: 0.2 nTPM
adipose tissue: 0.1 nTPM
basal ganglia: 0.1 nTPM
breast: 0.1 nTPM
cervix: 0.1 nTPM

Single-cell type

late spermatids: 3,917 nCPM
early spermatids: 683 nCPM
late primary spermatocytes: 24 nCPM
leydig cells: 4.5 nCPM
peritubular myoid cells: 4.4 nCPM
sertoli cells: 3.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hippocampal formation: 0.2 nTPM
midbrain: 0.2 nTPM
pons: 0.2 nTPM
thalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM187B as an antibody target. Whether an autoantibody or antibody against FAM187B could matter depends on whether native FAM187B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM187B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM187B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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